Related Products of 27492-84-8, These common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2.1) Diphenyl ether (500 mL, 3.15 mol) was added to a 1 L three-necked flask.After preheating the diphenyl ether in the three-neck flask to 220°C, add step 1.4).Compound II (45.25 g, 0.25 mol) and ethoxylated methyl malonate IIEthyl ester (58.32g, 0.27mol), reaction 1h, to obtain a mixture D;2.2) stirring the mixture D obtained in step 2.1) until it is cooled to 50 ° C to obtain a mixture E;2.3) The mixture E obtained in step 2.2) is filtered, the solid obtained after filtration is washed with methyl tert-butyl ether and dried to obtain compound III (yield 94.59percent)
Statistics shows that Methyl 4-amino-2-methoxybenzoate is playing an increasingly important role. we look forward to future research findings about 27492-84-8.
Reference:
Patent; Chongqing University; Dong Lichun; Hu Geng; Li Qi; Liu Dianqing; Wang Haoyuan; (19 pag.)CN107629001; (2018); A;,
Ester – Wikipedia,
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