Adding a certain compound to certain chemical reactions, such as: 16017-69-9, name is Ethyl 4-amino-2-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16017-69-9, name: Ethyl 4-amino-2-chlorobenzoate
The indicated chloro-aniline (1.02 g, 5.125 mmol) in methanol (13.0 mL) was treated with iodine monochloride (1.0 M in dichloromethane, 5.125 ml, 5.125 mmol) and the solution stirred for 1 hour at room temperature. The reaction mixture was poured into water, followed by aqueous/ethyl acetate work- up, and silica gel chromatography (ethyl acetate : hexanes (2:8) 3.0 % TEA) to give the titled compound.
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Reference:
Patent; MERCK & CO., INC.; WO2007/81335; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics