Adding a certain compound to certain chemical reactions, such as: 878207-28-4, name is Methyl 2-bromo-4,5-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 878207-28-4, Application In Synthesis of Methyl 2-bromo-4,5-difluorobenzoate
A solution of the intermediate methyl 2-bromo-4,5-difluorobenzoate (4.4g, 17.53mmol) and benzylamine (2.066g, 2.108mL, 19.28mmol) in N,N-dimethylsulfoxide was treated with dibasic potassium phosphate (12.21g, 70.1 mmol) and heated to 75C for 18 hours in an open tube. The reaction mixture was then diluted with of ethyl acetate (20OmL), washed with of water (4x15OmL) and saturated brine before drying (sodium sulfate) and evaporation to yield the title compound (5.3g). 1H NMR (CDCI3, 400 MHz):delta 3.86 (2H, s), 4.40, (2H, d), 4.69 (1 H, br s), 6.91 (1 H, d), 7.35 (5H, m), 7.63 (1 H, d)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-bromo-4,5-difluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; N.V. ORGANON; WO2009/138438; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics