Reference of 2216-92-4, The chemical industry reduces the impact on the environment during synthesis 2216-92-4, name is N-Phenylglycine Ethyl Ester, I believe this compound will play a more active role in future production and life.
Example 35 1, 1-Dioxo-5-phenyl-1, 2, 5-thiadiazolidin-3-one sodium salt A. N-sulfamoylated-N-phenylglycine ethyl ester; A solution N-phenylglycine ethyl ester (1.0 g, 5.58 mmol) and TEA (1.69 g, 16. 7 mmol) in MeCN, 3mL is added dropwise to a freshly prepared solution of sulfamoyl chloride (5.58 mmol) in MeCN (5mL) over 20 min. The mixture is stirred at room temperature (RT) for 16 h. The solvent is evaporated and the residue is partitioned between EtOAc and water. The organic layer is dried over anhydrous sodium sulfate (Na2SO4) and evaporated. The residue is flash chromatographed on silica gel using 30% No. 50% EtOAc in hexanes as eluent to afford the N-sulfamoylated-N-phenylglycine ethyl ester as a yellow solid : [M+1] + = 259.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Phenylglycine Ethyl Ester, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2003/82841; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics