Adding a certain compound to certain chemical reactions, such as: 14273-90-6, name is Methyl 6-bromohexanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14273-90-6, name: Methyl 6-bromohexanoate
General procedure: A solution of racemic norketamine (23) (0.4 g, 1.78 mmol), methyl2-bromoacetate (0.32 g, 2.14 mmol), KI (0.089 g, 0.54 mmol), K2CO3(0.74 g, 5.35 mmol) in MeCN (10 mL) was heated to a 100 °C in sealedtube for 12 h. The reaction mixture was cooled to room temperature,filtered and the solvent evaporated. The residue was purified by columnchromatography on silica gel eluting with EtOAc/hexanes (0?35percent) togive 2 (0.42 g, 80percent) as pale yellow oil. This was dissolved in Et2O(5 mL), cooled to 0 °C, and HCl in Et2O (2 M, 2.11 mmol) was addeddropwise. The solvent was evaporated under reduced pressure, the residuewas taken up in EtOAc (1 mL) and sonicated at room temperaturefor 2 min. The white precipitate was diluted with EtOAc (5 mL), filteredwashed with EtOAc and dried under vacuum to give
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Reference:
Article; Dimitrov, Ivaylo V.; Harvey, Martyn G.; Voss, Logan J.; Sleigh, James W.; Bickerdike, Michael J.; Denny, William A.; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1226 – 1231;,
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