Electric Literature of 344-14-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-14-9, name is Dimethyl 2-fluoromalonate, This compound has unique chemical properties. The synthetic route is as follows.
In a dry argon-protected reaction tube, 4.0 mol% of [Pd(C3H5)Cl]2, 8.0 mol% was added successively.The mixture was stirred at room temperature for 30 minutes, then 1.0 equiv. 5 (0.2 mmol) was added and stirring was continued for 10 minutes. 3.0 equiv. 8 (1.5 mmol) and 3.0 equiv. of Base (1.5 mmol) were added to the reaction tube and the reaction was stirred. After the reaction is completed, the solvent is removed under reduced pressure and the residue is subjected to a thin layer chromatography to give the desired product (petroleum ether/dichloromethane = 1/1, or petroleum ether/ethyl acetate = 10/1, v/v).
The chemical industry reduces the impact on the environment during synthesis Dimethyl 2-fluoromalonate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Tongji University; Zhao Xiaoming; Gao Ning; Cai Chengsi; Cai Juewang; (20 pag.)CN104926720; (2018); B;,
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