In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13412-12-9, name is Methyl 3-(methylamino)but-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 3-(methylamino)but-2-enoate
Step 2: 2-(4-Bromo-benzoyl)-3-[(E)-methylimino] -butyric acid methyl ester; [00439] 4-Bromobenzoyl chloride (17.14g, 78.1mmol) and 3-methylamino-but-2-enoic acid methyl ester (10. Og, 78.1mmol) were combined in THF (60OmL) and cooled to O0C. Pyridine (6.8mL, 85.9mmol) was added by syringe, and the reaction was stirred overnight at room temperature. Solid pyridine hydrochloride was observed on the flask walls, so the solution was decanted and then concentrated to 10% of its original volume. The residue was diluted with EtOAc (40OmL) and washed twice with H2O. The organic layer was dried, filtered, and concentrated to give the title compound.
The synthetic route of 13412-12-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; HUTCHINSON, John Howard; SEIDERS, Thomas Jon; ARRUDA, Jeannie M.; WO2010/68775; (2010); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics