344-14-9, These common heterocyclic compound, 344-14-9, name is Dimethyl 2-fluoromalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
First, put a stir bar in a 35 mL sealed tube, and then add methyl propargyl ether (28 muL, 0.33 mmol), 0.9 mL tetrahydrofuran (0.9 mL), and 2-chloroacetamidoquinoline (66.2 mg, 0.3 mmol), dimethyl 2-fluoromalonate (70.4 mg, 0.45 mmol). To the mixed solution were added CuI (5.7 mg, 0.03 mmol) and Cs2CO3 (117.3 mg, 0.36 mmol) in this order. The glass tube was filled with N2 for 3 minutes, the air was fully expelled, the nozzle was sealed with a cock, and the reaction was stirred at 800C for 1.5 hours. After the reaction was completed, the system was cooled to room temperature, 2 ml of distilled water was added to the reaction system, and ethyl acetate was used. After extraction, the organic phases were combined, and the solvent of the organic phase was distilled off under reduced pressure. 86.1 mg of the product was separated by silica gel column chromatography in 4d, and the yield was 71%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 344-14-9.
Reference:
Patent; Anyang Normal University; Lv Yunhe; Pu Weiya; Wang Xin; Wang Xiaoxing; (15 pag.)CN110627718; (2019); A;,
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