Some common heterocyclic compound, 3697-68-5, name is Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate, molecular formula is C7H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H12O3
[0373] To a stirring ice-cooling solution of compound 72(200 mg, 1.39 mmol) and triethylamine (280 mg, 2.77 mmol)in DCM (10 ml), was added methanesulfonyl chloride (190mg, 1.66 mmol, dissolve in 1 ml DCM) dropwise. The reactionmixture was stirred 1 hat oo C., then diluted with DCM(20 ml), the organic phase was washed with water and brine,dried over Na2S04 , filtered and concentrated to afford crudecompound 73 (300 mg, yield 97%) as a colorless oil, useddirectly in the next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3697-68-5, its application will become more common.
Reference:
Patent; Gao, Daxin; Yang, Heping; Yu, Yajun; US2014/329800; (2014); A1;,
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