Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, This compound has unique chemical properties. The synthetic route is as follows., category: esters-buliding-blocks
568 g of anhydrous xylene and 139.0 g of the product prepared in example 1 were loaded into a 2-litre flask fitted with a stirrer, thermometer, dropping funnel and condenser. 645 g of a 30% xylene solution of 2-ethyl hexyl 4-aminobenzoate was added in 30 minutes to the mixture, stirred at 90C. When the addition had been completed, the mixture was maintained at 90C for 15 min and then heated to 125C in 60 minutes, obtaining a thick whitish suspension. The mixture was maintained under stirring at 125C for 3 hours, during which time a gradual reduction in the development of hydrochloric acid and an increase in the fluidity of the mixture was observed. After cooling to 80-90C, 280 g of 15% aqueous sodium carbonate was added cautiously. After 30 minutes’ mixing at 70-80C, stirring was interrupted and the underlying alkaline aqueous phase was discharged. After two further aqueous washes, the residual water was removed by azeotropic distillation under atmospheric pressure, followed by distillation of xylene to concentrate the solution. 680 g of whitish dispersion was obtained, containing approx. 275 g of the desired product, which was characterised by UPLC-MS. The dispersion “as is” was used for the subsequent stages of synthesis.
According to the analysis of related databases, 26218-04-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; 3V SIGMA S.P.A.; MAESTRI, Francesco; BEMPORAD, Luca; BERTE’, Ferruccio; WO2013/156272; (2013); A1;,
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