Adding a certain compound to certain chemical reactions, such as: 126541-82-0, name is Methyl 3-amino-4-(trifluoromethyl)benzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 126541-82-0, Formula: C9H8F3NO2
Step A: Methyl 3-bromo-4-(trifluoromethyl)benzoatet-BuONO (79.0 g, 765 mmol) was added to a solution of methyl 3-amino-4- (trifluoromethyl)benzoate (67.0 g, 306 mmol) and CuBr (88.0 g, 612 mmol) in acetonitrile (1000 mL) at 0 C, and the resulting mixture was warmed to 25 C and stirred for 12 h. The mixture was then poured into EtOAc (600 mL) and filtered. The filtrate was washed with an aqueous HCl solution (1 M, 200 mL x 3), then brine (200 mL), dried over Na2S04 and concentrated. The residue was purified by column chromatography on silica gel (PE:EA = 200: 1) to give the title compound. MS: mlz = 283, 285 (M + 1). *H NMR (400 MHz, CDC13) delta 8.37 (s, 1H), 8.06 (d, J = 8.0 Hz, 1H), 7.77 (d, J= 8.0 Hz, 1H), 3.97 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-4-(trifluoromethyl)benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; MITCHELL, Helen; FRALEY, Mark, E.; COOKE, Andrew, J.; CHEN, Yi-Heng; STUMP, Craig, A.; ZHANG, Xu-Fang; MCCOMAS, Casey, C.; SCHIRRIPA, Kathy; MCWHERTER, Melody; MERCER, Swati, P.; BABAOGLU, Kerim; MENG, Dongfang; WU, Jane; LIU, Ping; WOOD, Harold, B.; BAO, Jianming; LI, Chun Sing; MAO, Qinghua; QI, Zhiqi; (263 pag.)WO2015/148344; (2015); A2;,
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