Electric Literature of 35120-18-4, A common heterocyclic compound, 35120-18-4, name is Ethyl 1-bromocyclobutanecarboxylate, molecular formula is C7H11BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 6-methoxyquinoline-4-thiol 4b (477 mg, 2.5 mmol), ethyl 1-bromo cyclobutanecarboxylate (620 mg, 2.9 mmol) and cesium carbonate (326 mg, 7.5 mmol) Was added to 10 mL of N, N-dimethylformamide. The reaction solution was heated to 60 DEG C and stirred for 2 hours. 50 ml of water was added to the reaction solution, and the mixture was extracted with ethyl acetate (50 ml x 4). The organic phases were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the title compound ethyl 1 – ((6-methoxyquinolin-4-yl) thio) cyclobutanecarboxylate 4c (620 mg, brown oil), yield: 78%.
The synthetic route of 35120-18-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Hengrui Pharmaceutical Co., Ltd; Jiangsu Hengrui Medicine Co.,Ltd.; Peng, Jian Biao; Sun, Pia Ohyang; Lan, Jiong; Koo, Cheon Yang; Lee, Siaotao; Liu, Bonnian; Han, Quanzhou; Hoo, Kwiye; Jean, Pang Pang; Dong, Qing; Cao, Guo Qing; (67 pag.)KR2016/6207; (2016); A;,
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