Synthetic Route of 27798-60-3, The chemical industry reduces the impact on the environment during synthesis 27798-60-3, name is Methyl 2-Methoxyphenylacetate, I believe this compound will play a more active role in future production and life.
A 5 OOmL round-bottom flask is charged with methyl 2-(2-methoxyphenyl)acetate (8.496 g, 47 mmol, leq) and THF (200mL). The homogeneous mixture is cooled to 0 C in an ice bath. Lithium diisopropyl amide (23.5mL of a 2.OM solution in heptane/THF) is added,maintaining a temperature less than 3C. The reaction is stirred 45 minutes at this reduced temperature. Benzyl bromide (5.6mL, 47mmol, leq) is added dropwise. The reaction is allowed to gradually warm to room temperature and is stirred for 18 hours. The reaction is quenched with iN HC1 and extracted 3 times with equal portions of EtOAc. The combined extracts are washed with H20 and brine, dried over Na2SO4,filtered, and concentrated. The residue is purified over silica to afford 4.433g (35%) of the desired compound. ESI+ MS 293 (M+Na).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-Methoxyphenylacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AERPIO THERAPEUTICS INC.; PETERS, Kevin; SHALWITZ, Robert; JANUSZ, John; SMITH, Alexander; WO2014/145068; (2014); A1;,
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