These common heterocyclic compound, 13031-39-5, name is 3-Chlorophenyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H7ClO2
i) 4-Chloro-2-hydroxyacetophenone In a 500 mL of round bottom flask purged with argon was placed 26.00 g (0.153 mol) of 3-acetoxychlorobenzene, cooled with ice bath. Then 30.00 g (0.225 mol) of AlCl3 was added in portions. The resulting mixture was heated to 140 C. for 2 h (caution: vigorous evolution of gas) and then cooled to 0 C. treated with 15 mL of conc. HCl in 100 mL of ice water, extracted with EtOAc (3×300 mL). The combined organic extracts were washed with brine and dried (Na2SO4). Removal of the solvent gave 24.00 g (92%) of the title compound as a light yellow liquid: 1H NMR (250 MHz, CDCl3) d 10.7 (s, 1H), 7.65 (d, J=8.6 Hz, 1H), 6.98 (d, J=1.8 Hz, 1H), 6.87 (dd, J=1.8, 8.6 Hz, 1H), 2.61 (s, 3H).
The synthetic route of 3-Chlorophenyl acetate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SmithKline Beecham Corporation; US6353116; (2002); B1;,
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