In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13031-39-5 as follows. HPLC of Formula: C8H7ClO2
3-chlorophenyl acetate (starting material 2) was mixed with aluminium chloride (3 eq). The mixture was heated at 200 C. for 1 hour. The reaction medium was cooled to room temperature then poured in ice. The aqueous phase was extracted with methylene chloride which was dried on magnesium sulfate then vacuum evaporated. Purification was by silica gel chromatography (elution: cyclohexane/ethyl acetate 95:5). 1 H NMR CDCl3 deltappm: 3.41 (s, 3 H), 6.81 (dd, J=8.82 Hz, J=1.47 Hz, 1H), 6.91 (d, J=1.47 Hz, 1H), 7.60 (d, 8.82 Hz, 1 H), 12.33 (s, 1H) Reference: Chen et al, J Chem Soc, 1958, 146-148.
According to the analysis of related databases, 13031-39-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENFIT; US2005/171149; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics