Adding a certain compound to certain chemical reactions, such as: 54810-63-8, name is Methyl 2-chloro-5-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54810-63-8, Recommanded Product: Methyl 2-chloro-5-methoxybenzoate
Methyl (2-chloro-5-methoxy)benzoate (18) (1.19 g, 6.47 mmol) was stirred vigorously in neat aqueous ammonia (28%, 7.8 mL) at room temperature. After 24 h, the resulting mixture was treated with chloroform and the separated organic phase washed with aqueous hydrochloric acid (5 M, 55 mL), water (40 mL), brine (40 mL) then dried (MgSO4), filtered and concentrated under reduced pressure to give 19 as a white powder (0.93 g, 78% yield). m.p. 125.3-126.9 C; IR (ZnSe): 3372, 3178, 1650, 1480, 1461, 1446, 1239, 1028, 821 cm-1; 1H NMR (300 MHz, MeOD): delta 7.34 (1H, d, J = 8.8 Hz), 7.05 (1H, d, J = 2.9 Hz), 7.00 (1H, dd, J = 2.9 and 8.8 Hz), 3.81 (3H, s) ppm; 13C NMR (75 MHz, MeOD): delta 172.1, 159.8, 137.9, 132.0, 122.8, 117.9, 115.2, 56.2 ppm; LRMS (GC-MS): 185 ([M], 60%), 169 ([M-NH2], 100%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-chloro-5-methoxybenzoate, and friends who are interested can also refer to it.
Reference:
Article; Callis, Timothy B.; Reekie, Tristan A.; O’Brien-Brown, James; Wong, Erick C.N.; Werry, Eryn L.; Elias, Nabiha; Jorgensen, William T.; Tsanaktsidis, John; Rendina, Louis M.; Kassiou, Michael; Tetrahedron; vol. 74; 12; (2018); p. 1207 – 1219;,
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