Application of 33491-30-4, These common heterocyclic compound, 33491-30-4, name is 8-Bromo-2H-chromen-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: General synthetic procedure for 3a/3b/3c: 6-Bromocoumarin(0.5 g, 2.23 mmol), (4-ethynyl)benzaldehyde (0.29 g, 2.23 mmol)were dissolved in THF-triethylamine (1:1, v/v, 120 mL) and themixture was deaerated for 10 min with nitrogen bubbling and thenPd(PPh3)2Cl2 (31 mg, 2mol%), PPh3 (23 mg, 4 mol%)and CuI (8 mg,2mol%) were added. The solution was deaerated for an additional5 min; after that, reaction was left under nitrogen at 60C for 12 h.After completion of the reaction, the reaction mixture was cooledat room temperature and the solvent was evaporated. The crudeproduct was dissolved in CH2Cl2 and purified by a columnchromatography on a silica gel using (chloroform) as an eluent.
Statistics shows that 8-Bromo-2H-chromen-2-one is playing an increasingly important role. we look forward to future research findings about 33491-30-4.
Reference:
Article; Reddy, T. Sheshashena; Choi, Myung-Seok; Journal of Photochemistry and Photobiology A: Chemistry; vol. 351; (2018); p. 108 – 114;,
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