In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18830-44-9, name is Methyl 3,3,3-trifluoropropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H5F3O2
Put 67.1g of sodium hydroxide and 300g of deionized water into a 500ml reaction bottle, cool the ice water bath to 5 10 , drop 216.6g of methyl trifluoropropionate above, control the internal temperature below 30 , and continue stirring after the dripping 30min.Concentrated hydrochloric acid was added dropwise to the reaction bottle until the pH of the reaction solution was below 2, and stirring was continued for 30 min after completion of the drop.300 g of dichloromethane was added to the reaction flask for extraction twice, and the dichloromethane was concentrated and recovered to obtain crude trifluoropropionic acid.Set up a vacuum distillation device, vacuum distillate crude trifluoropropionic acid, collect 83 ~ 85 fraction (vacuum degree -0.097MPa), which is 3,3,3-trifluoropropionic acid, weight 199g, purity 99.2%, yield 88.0%, total reaction yield 66.2%.
The synthetic route of 18830-44-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hunan Youse Chenzhoufu Chemical Co., Ltd.; Wang Gang; Peng Zhimin; Li Zhipeng; Yin Demei; Zhang Zhenhua; (8 pag.)CN110903183; (2020); A;,
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