Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25415-67-2, name is Ethyl 4-methylpentanoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 4-methylpentanoate
REFERENCE EXAMPLE 11 Ethyl 2-(4-bromophenylacetyl)-4-methyl-3-oxopentanoate To a suspension of NaH (7.6 g, 158 mmol) in toluene (142 mL) at 0 C. was added dropwise a solution of ethyl isobutylylacetate (20 g, 126 mmol) in toluene (52 mL) and the resulting solution was stirred under an argon atmosphere for 30 min. Then, a solution of 4-bromophenylacetyl chloride (29.4 g, 126 mmol, prepared as described in reference example 1) in toluene (98 mL) was slowly added and the reaction mixture stirred at room temperature overnight. The resulting solution was poured into H2 O-EtOAc and extracted with H2 O (2*). The organic phase was washed with brine, the aqueous phase was acidified and extracted with EtOAc, and the combined organic phases were dried and concentrated. The residue was chromatographed on silica gel (hexane-EtOAc, 5%) to afford the title compound (29 g, 65%). 1 H-NMR-(CDCl3) delta (TMS): 1.16 (d, J=6.4 Hz, 6H), 1.31 (t, J=7.2 Hz, 3H), 3.09 (q, J=6.4 Hz, 1H), 3.87 (s, 2H), 4.26 (q, J=7.2 Hz, 2H), 7.12 (d, J=8 Hz, 2H), 7.41 (d, J=8 Hz, 2H), 17.49 (s, 1H).
The synthetic route of 25415-67-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; J. Uriach & Cia, S.A.; US5827863; (1998); A;,
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