Synthetic Route of 85920-63-4, These common heterocyclic compound, 85920-63-4, name is 5-(1-Hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Enaminone 15 (3.0 g, 15.7 mmol, 1.0 equiv.) and freshly ground acyl Meldrum’s acid (8.76 g, 47.1 mmol, 3.0 equiv.) were dissolved in toluene (157 mL) and the solution was heated to reflux for 45 min. Removal of the volatiles yielded a brown semisolid. The crude material was purified using acidified silica gel* and 7:1 hexanes: ethyl acetate as the eluent to afford 14 as a white solid (1.55?g, 6.73?mmol, 43%).
The synthetic route of 85920-63-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Eliasen, Anders M.; Chin, Matthew R.; Axelrod, Abram J.; Abagyan, Ruben; Siegel, Dionicio; Tetrahedron; vol. 74; 26; (2018); p. 3238 – 3245;,
Ester – Wikipedia,
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