Electric Literature of 24393-53-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24393-53-1 name is (E)-Ethyl 3-(4-bromophenyl)acrylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A method for constructing a quaternary carbon ring by visible light catalysis [2+2] reaction, comprising the following steps: The ruthenium complex 1 is used as a visible light catalyst, and 1.3 mg of the catalyst is added to 2 mL of 1,2-dichloroethane.0.2 mmol of (E)-ethyl-3-p-bromophenyl acrylate (corresponding R2 is p-bromophenyl, R3 is ethoxy), 1.0 mmol of 1,1-diphenylethylene (corresponding R1 is benzene) The base, R2 is a phenyl group) wherein the concentration of the visible light catalyst is 1.0 x 10-3 M. Pass argon for ten minutes,Then, with 450 nm ± 10 nm Blue LEDs, the light was illuminated in an argon atmosphere at 25 C for 5 h.After the reaction is completed, it is directly dried and separated by a column. Nuclear magnetic resonance spectrum, carbon spectrum,Mass spectrometryThe compound is a racemic ethyl-(2R)-2-(p-bromophenyl)-3,3-diphenyl-cyclobutyl-1-carboxylate.The conversion of the starting material was 100% and the yield of the cyclobutane product was 85%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Ethyl 3-(4-bromophenyl)acrylate, and friends who are interested can also refer to it.
Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Wu Lizhu; Lei Tao; Zhao Leimin; Zhou Chao; Liu Zan; Tong Zhenhe; (89 pag.)CN108623425; (2018); A;,
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