In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 369-26-6, name is Methyl 3-amino-4-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 369-26-6
To a suspension of compound 21 (1.01 g, 6 mmol) in hydrochloric acid (13 ml, 37%) at 0 C was added a cold solution of sodium nitrite (0.50 g, 7.2 mmol) in water (5 ml) maintaining the temperature below 5 C. The resultant solution was stirred in an ice bath for 30 min before the addition of a solution of tin(II) chloride dihydrate (4.06 g, 18 mmol) in hydrochloric acid (5 ml, 37%) maintaining the temperature below 5 C. The resultant suspension was stirred at 0 C for 3 h and the suspension filtered and then dissolved in DCM, washed with saturated NaHCO3, dried over by MgSO4 to get the compound 22 (1.01 g, 92%). 1H NMR (CDCl3, 400 MHz): delta 7.79-7.77 (m, 1H), 7.46 (s, 1H), 7.04-6.99 (m, 1H), 5.48 (br, 1H), 3.91 (s, 3H) 3.62 (br, 2H). ESI-HRMS: m/z calcd for C8H9FN2O2 [M+H]+ 185.0682 found 185.0664.
The synthetic route of 369-26-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lu, Chaocao; Htan, Bu; Fu, Shitao; Ma, Chunmiao; Gan, Quan; Tetrahedron; vol. 75; 30; (2019); p. 4010 – 4016;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics