Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H9BrO2
Degas a suspension of methyl 2-(2-bromophenyl)acetate (156.6 g, 684 Tnmoi), bis(inacoiato)diboron (194.9 g, 752 mmoi), and potassium acetate (135,6 g, 1.4 mol) in N-methylpyrroiidone (940 mL) with three vacuuni?nitrogen cycles, Add (1,1 bis(diphenyiphosphino)ferrocene)palladiurn(H) chloride (11,4 g, 13,7 nunol) and heat at 80C. After 15 hours add (1 , I -bis(diphenyiphosphino)ferrocene)palladiuni(II) chloride(11,4 g, 13.7 mmoi) and stir at 90 C for 24 hours, Cool to ambient tern perare and pour over a mixture of ice and water (3 L), and methyl tertiary butyl ether (1 L) was added, Stir mixture, filter through a pad of Celite and separate layers, Extract from aqueous with methyl tertiary hutyl ether (2×500 niL), Wash combined organics with water (2×500 mL), brine (500 mL), dry over sodium sulfate and concentrate. Purify the residue byflash chromatography, elating with hexane: ethyl acetate (9:1) to give the title compound as a white solid (160,6 g, 581.6 mrnol, 85%). MS (rn/z): 277(M+i),
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57486-69-8.
Reference:
Patent; ELI LILLY AND COMPANY; BENHADJI, Karim A.; MASSARD, Christophe; SORIA, Jean-Charles; (43 pag.)WO2016/168014; (2016); A1;,
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