Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 685892-23-3, name is Methyl 2-bromo-6-chlorobenzoate, A new synthetic method of this compound is introduced below., Product Details of 685892-23-3
A mixture of methyl 2-bromo-6-chlorobenzoate (750 mg, 3 mmol), (PPh 3) 4 Pd (345 mg, 0.3 mmol) and cyclobutyl zinc bromide (0.5 M in THF, 12 mL) was mixed under N 2 protection. The mixture was stirred under N 2 at 70 C. for 12 h. The mixture was extracted with EtOAc and water. The organic phase was washed with brine, dried over Na 2 SO 4, filtered and concentrated. The residue was purified by flash chromatography (PE: EtOAc = 50: 1) to give the title compound.
The synthetic route of 685892-23-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mrck Sharp and Dohme Corp; Blair T, Lapointe; Peter H, Fuller; Hakan, Gunaydin; Kun, Liu; Daneille F, Molinari; Qinglin, Pu; Mark E, Scott; B Wesely, Trotter; Hongjun, Zhang; (117 pag.)JP2018/531957; (2018); A;,
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