Venukadasula, Phanindra K. M. et al. published their research in ACS Medicinal Chemistry Letters in 2016 | CAS: 16413-26-6

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of 3-Cyanophenylisocyanate

Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation was written by Venukadasula, Phanindra K. M.;Owusu, Benjamin Y.;Bansal, Namita;Ross, Larry J.;Hobrath, Judith V.;Bao, Donghui;Truss, Jackie W.;Stackhouse, Murray;Messick, Troy E.;Klampfer, Lidija;Galemmo, Robert A.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Application In Synthesis of 3-Cyanophenylisocyanate This article mentions the following:

In this letter the authors report first nonpeptide inhibitors of hepatocyte growth factor (HGF) activation. These compounds inhibit the three proteases (matriptase, hepsin, and HGF activator) required for HGF maturation. The authors show that several compounds I [Z = Me, HO, HOCH2, MeOCH2] block activation of fibroblast-derived pro-HGF, thus preventing fibroblast-induced scattering of DU145 prostate cancer cells. One of these compounds (SRI 31215) I [Z = Me] is very soluble (91 μM) and has excellent microsome stability (human t1/2 = 162 min; mouse t1/2 = 296 min). In mouse I [Z = Me] has an in vivo t1/2 = 5.8 h following IV administration. The high solubility of I [Z = Me] and IV t1/2 make this compound a suitable prototype “triplex inhibitor” for the study of the inhibition of HGF activation in vivo. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Application In Synthesis of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics