Design of Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 2. was written by Freeman, George A.;Andrews, C. Webster III;Hopkins, Andrew L.;Lowell, Gina S.;Schaller, Lee T.;Cowan, Jill R.;Gonzales, Stephen S.;Koszalka, George W.;Hazen, Richard J.;Boone, Lawrence R.;Ferris, Rob G.;Creech, Katrina L.;Roberts, Grace B.;Short, Steven A.;Weaver, Kurt;Reynolds, David J.;Milton, John;Ren, Jingshan;Stuart, David I.;Stammers, David K.;Chan, Joseph H.. And the article was included in Journal of Medicinal Chemistry in 2004.Synthetic Route of C11H20O4 This article mentions the following:
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the x-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Synthetic Route of C11H20O4).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C11H20O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics