Chemical constituents from the rhizomes of Polygonatum sibiricum Red. and anti-inflammatory activity in RAW264.7 macrophage cells was written by Zhao, Huan;Wang, Qiao-Lian;Hou, Shu-Bing;Chen, Guang. And the article was included in Natural Product Research in 2019.Reference of 1190-39-2 This article mentions the following:
Chem. investigation of the rhizomes of Polygonatum sibiricum Red. led to the identification of 27 constituents. Among them, a total of 16 compounds were obtained from Polygonatum for the first time, in which, and were also firstly isolated as natural products. Anti-inflammatory activity studies on 13 isolated compounds showed that 灏?carboline constituents, especially compounds and , significantly inhibited the expression of NO, TNF-浼? IL-6 and IL-1灏?in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells. Moreover, western blotting anal. demonstrated that compound significantly inhibited the expression of COX-2, iNOS and the activation of NF-榄廈, suggesting that 灏?carboline structures may play an important role in inhibition of NF-榄廈 signaling pathway, which thereby inhibits the production of inflammatory factors. The present research may not only help further elucidation of the anti-inflammatory mechanism of P. sibiricum Red., but also provide the potential bioactive mols. for inflammatory diseases research. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Reference of 1190-39-2).
malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Reference of 1190-39-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics