Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 灏?ketoester-functionalized indoles was written by Wang, Sasa;Liu, Miao;Chen, Xinzheng;Wang, Huifei;Zhai, Hongbin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C12H14O3 This article mentions the following:
A copper-catalyzed reaction of ethynyl benzoxazinanones with readily accessible 灏?ketoesters via a decarboxylative propargylation/hydroamination sequence was developed. This protocol furnished a diverse range of C3 灏?hydroxyester-functionalized indoles I [R1 = H, 4-Me, 5-Me, 5-OMe, etc.; R2 = Me, Ph, Bn, etc.; R3 = Et, i-Pr, Bn, etc.] in good to excellent yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Computed Properties of C12H14O3).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C12H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics