Copper-Mediated Deuterotrifluoromethylation of 浼?Diazo Esters was written by Hu, Mingyou;Xie, Qiqiang;Li, Xinjin;Ni, Chuanfa;Hu, Jinbo. And the article was included in Chinese Journal of Chemistry in 2016.Name: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:
A copper-mediated deuterotrifluoromethylation of 浼?diazo esters RC(=N2)CO2CH2CH3 (R = C6H5, 4-BrC6H4CH2, octanyl, naphth-1-yl, etc.) under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds RC(CF3)(D)(CO2CH2CH3). This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some exptl. evidences to support the previously proposed trifluoromethylation mechanism. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Name: Ethyl 2-(4-fluorophenyl)acetate).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Ethyl 2-(4-fluorophenyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics