Combinatorial Discovery of Fluorescent Pharmacophores by Multicomponent Reactions in Droplet Arrays was written by Burchak, Olga N.;Mugherli, Laurent;Ostuni, Mariano;Lacapere, Jean Jacques;Balakirev, Maxim Y.. And the article was included in Journal of the American Chemical Society in 2011.Application In Synthesis of Methyl 2-aminonicotinate This article mentions the following:
Fluorescence imaging in clin. diagnostics and biomedical research relies to a great extent on the use of small organic fluorescent probes. Because of the difficulty of combining fluorescent and mol.-recognition properties, the development of such probes has been severely restricted to a number of well-known fluorescent scaffolds. Here we demonstrate that autofluorescing druglike mols. are a valuable source of bioimaging probes. Combinatorial synthesis and screening of chem. libraries in droplet microarrays allowed the identification of new types of fluorophores. Their concise and clean assembly by a multicomponent reaction presents a unique potential for the one-step synthesis of thousands of structurally diverse fluorescent mols. Because they are based upon a druglike scaffold, these fluorophores retain their mol. recognition potential and can be used to design specific imaging probes. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Application In Synthesis of Methyl 2-aminonicotinate).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 2-aminonicotinate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics