Silver-mediated annulation between 5-H-1,2,3-thiadiazoles and 1,3-dicarbonyl compounds to construct polysubstituted furans was written by Feng, Mengxia;Jiang, Huanfeng;Huang, Liangbin. And the article was included in Organic Chemistry Frontiers.Recommanded Product: 13669-10-8 This article mentions the following:
An efficient synthesis of polysubstituted furans I [R = Ph, furan-2-yl, 4-MeSC6H4, etc.; R1 = Me, i-Pr, Ph, etc.; R2 = CN, C(O)Me, C(O)OEt, etc.] by Ag(I)-mediated annulation between 5-H-1,2,3-thiadiazoles and 1,3-dicarbonyl compounds was reported. The methodol. was characterized by availability of starting materials, good functional group tolerance, and the successful construction of heterocycle-substituted furans. The utilization of this method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, preliminary control experiments ruled out the formation of an alkynyl silver intermediate. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 13669-10-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics