2-Pyrrolidinylideneureas, a new class of central nervous system agents was written by Rasmussen, C. R.;Gardocki, Joseph F.;Plampin, James N.;Twardzik, Barbara L.;Reynolds, Brian E.;Molinari, Albert J.;Schwartz, Norman;Bennetts, Walter W.;Price, Beth E.;Marakowski, Janis. And the article was included in Journal of Medicinal Chemistry in 1978.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:
Pyrrolidinylideneureas (I) were prepared and screened for pharmacol. activity. I (X = H, 4-NO2, 3-Br, 3-F, 3-Cl, 3-Me) had anxiolytic activity. I 2,6-disubstituted with Me, Cl, and Br imparted potent muscle-relaxant properties which appear to be centrally mediated. A significant separation of the anxiolytic and muscle-relaxant properties fromother CNS activities, eg, anticonvulsant, sedative, and hypnotic, was achieved. I were prepared by treating 2-imino-1-methylpyrrolidines with aryl isocyanates. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of 3-Cyanophenylisocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics