Synthesis and antiinflammatory activity of cis- and trans-6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepinacetic and -oxepinacetic acids was written by Kurokawa, Mikio;Uno, Hitoshi;Nakamura, Hideo;Sato, Fuminori;Naruto, Shunsuke. And the article was included in Journal of Medicinal Chemistry in 1990.Synthetic Route of C11H14O3 This article mentions the following:
Eight cis– and trans-6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepin- and -oxepinacetic acids I (X = S, O; R = 2- and 3-CH2CO2H and -CHMeCO2H) were prepared, and their antiinflammatory activities were examined in the rat carrageenan hind-paw edema test. The antiinflammatory activity depended on the configurations at C-6a, C-10a, and C-2 of the acetic moiety. The 6a,10a-trans compounds exhibited considerable antiinflammatory activity, while the 6a,10a-cis compounds were inactive. Among the trans compounds, I (X = S, O; R = 3-CHMeCO2H) showed antiinflammatory activity superior to that of indomethacin. Trans phenethyl ester I (X = S; R = 3-CHMeCO2CH2CH2Ph) (II) showed potent antiinflammatory activity, and its safety index was >14 times as high as that of indomethacin. II is the most favorable compound with high antiinflammatory activity and little ulcerogenicity. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Synthetic Route of C11H14O3).
Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Synthetic Route of C11H14O3
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics