Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: A new pronucleotide effective against Epstein-Barr virus was written by Wang, Ruifang;Kern, Earl R.;Zemlicka, Jiri. And the article was included in Antiviral Chemistry & Chemotherapy in 2002.COA of Formula: C8H14O4 This article mentions the following:
Methylenecyclobutane analogs of 2′-deoxyadenosine, 2′-deoxyguanosine and 2′-deoxycytidine, and the corresponding phosphoralaninate pronucleotides comprising adenine and guanine bases, were synthesized as potential antiviral agents. Phosphoralaninate of adenine methylenecyclobutane was a potent inhibitor of replication of Epstein-Barr virus (EBV) in Daudi cell culture. Phosphoralaninate of guanine analog was inactive but both pronucleotides were substrates for porcine liver esterase. Adenine methylenecyclobutane analog was deaminated by adenosine deaminase. In the experiment, the researchers used many compounds, for example, Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3COA of Formula: C8H14O4).
Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C8H14O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics