In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6290-49-9, name is Methyl 2-methoxyacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 2-methoxyacetate
Intermediate 16; 5-(Methoxy)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone To a three-neck 500 mL round-bottomed flask, equipped with mechanical stirring, were added toluene (100 mL) and metallic sodium (5.75 g; 0.25 moles). A mixture of methyl methoxyacetate (25 mL; 0.25 moles) and ethyl formate (20 mL; 0.25 moles) was added dropwise to the system using an addition funnel. An external water bath was used to keep the system below 30 C. throughout the addition. The system was stirred at room temperature for 16 h. The liquid phase was then decanted and the remaining gummy solid was treated with thiourea (19 g; 0.25 moles) and ethanol (50 mL). The system was heated to reflux for 4 h and cooled to room temperature. The light pink solid was collected by filtration and dissolved in 125 mL of water. The solution was acidified (pH 4-5) with concentrated HCl. The solid precipitated was collected by filtration, washed with water and dried under high vacuum Intermediate 16 (22 g; 56% yield) was obtained. MS: (M+H)-=159.
The synthetic route of 6290-49-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Johnson, Neil W.; Bryan, Deborah L.; US2008/182852; (2008); A1;,
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