Adding a certain compound to certain chemical reactions, such as: 344-14-9, name is Dimethyl 2-fluoromalonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 344-14-9, Recommanded Product: Dimethyl 2-fluoromalonate
(R)-7-Fluoro-8-hydroxy-1 -((S)-1 -(4-methoxyphenyl)ethyl)-4- (trifluoromethyl)-3,4-dihydro-1 H-pyrimido[1 ,2-a]pyrimidin-6(2H)-one can be prepared in the following way. 30 g of methyl fluoromalonate and 10.8 g of anhydrous sodium methoxide are added, at ambient temperature and under an argon atmosphere, to a suspension of 12 g of (S)-1 -[(S)-1 -(4-methoxyphenyl)ethyl]- 4-trifluoromethyl-1 ,4,5,6-tetrahydropyrimidin-2-ylamine in 150 ml of methanol. The mixture obtained is then heated at reflux. After one hour of stirring at reflux, the reaction is complete according to the verification by LC/MS. After cooling, the reaction mixture is evaporated to dryness under reduced pressure. The residue obtained is taken up with 100 ml of cold water. 36% HCI is added dropwise to pH = 6. The solid formed is filtered off and then washed three times with ethyl ether. The solid is oven-dried under vacuum in the presence of P2O5, so as to give 15 g of (R)-7-fluoro-8-hydroxy-1 -((S)-1 -(4- methoxyphenyl)ethyl)-4-(trifluoromethyl)-3,4-dihydro-1 H-pyrimido[1 ,2- a]pyrimidin-6(2H)-one, which is used as it is in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dimethyl 2-fluoromalonate, and friends who are interested can also refer to it.
Reference:
Patent; SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; LETALLEC, Jean-Philippe; MARCINIAK, Gilbert; RONAN, Baptiste; VIVET, Bertrand; WO2013/190510; (2013); A2;,
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