Identification and structure-activity relationships of 1-aryl-3-piperidin-4-yl-urea derivatives as CXCR3 receptor antagonists was written by Allen, Daniel R.;Bolt, Amanda;Chapman, Gayle A.;Knight, Roland L.;Meissner, Johannes W. G.;Owen, David A.;Watson, Robert J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Category: esters-buliding-blocks This article mentions the following:
The synthesis and biol. evaluation of a series of 1-aryl-3-piperidin-4-yl-urea derivatives, e.g., I, as small-mol. CXCR3 antagonists is described. SAR studies resulted in significant improvement of potency and physicochem. properties and established the key pharmacophore of the series, and led to the identification of 9t, which exhibits an IC50 of 16 nM in the GTPγS35 functional assay. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Category: esters-buliding-blocks).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics