Enantioselectivity switch in asymmetric Michael addition reactions using phosphonium salts was written by Fang, Guosheng;Wang, Hongyu;Zheng, Changwu;Pan, Lu;Zhao, Gang. And the article was included in Organic & Biomolecular Chemistry in 2021.Name: malonic acid dibutyl ester This article mentions the following:
Here,a general method to obtain both enantiomeric products via fine tuning the hydrogen-bonding interactions of phosphonium salts was reported. Amino acid derived phosphonium salts and dipeptide derived phosphonium salts exhibited different properties for controlling the transition state, which could efficiently promote the Michael addition reaction to give opposite configurations of products with high yields and enantioselectivities. Preliminary investigations on the mechanism of the reaction and applications of the products were also performed. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Name: malonic acid dibutyl ester).
malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: malonic acid dibutyl ester
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics