Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1 was written by Mould, Daniel P.;Bremberg, Ulf;Jordan, Allan M.;Geitmann, Matthis;Maiques-Diaz, Alba;McGonagle, Alison E.;Small, Helen F.;Somervaille, Tim C. P.;Ogilvie, Donald. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.SDS of cas: 173341-02-1 This article mentions the following:
A series of reversible inhibitors of lysine specific demethylase 1 (LSD1) with a 5-hydroxypyrazole scaffold have been developed from compound 7, which was identified from the patent literature. Surface plasmon resonance (SPR) and biochem. anal. showed it to be a reversible LSD1 inhibitor with an IC50 value of 0.23 μM. Optimization of this compound by rational design afforded compounds with Kd values of <10 nM. In human THP-1 cells, these compounds were found to upregulate the expression of the surrogate cellular biomarker CD86. Compound 11p was found to have moderate oral bioavailability in mice suggesting its potential for use as an in vivo tool compound In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1SDS of cas: 173341-02-1).
tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 173341-02-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics