1-(2H-Azirine-2-carbonyl)benzotriazoles: building blocks for the synthesis of pyrrole-containing heterocycles was written by Galenko, Ekaterina E.;Shakirova, Firuza M.;Bodunov, Vladimir A.;Novikov, Mikhail S.;Khlebnikov, Alexander F.. And the article was included in Organic & Biomolecular Chemistry in 2020.Synthetic Route of C9H10O3S This article mentions the following:
A one-pot method was developed for the preparation of 2H-azirine-2-carbonylbenzotriazoles I [R1 = tBu, Ph, 4-FC6H4, etc.] synthesized via the reaction of benzotriazole with 2H-azirine-2-carbonyl chlorides, which were generated by the Fe(II)-catalyzed isomerization of 5-chloroisoxazoles. The Co(II)-catalyzed reaction of 2H-azirine-2-carbonylbenzotriazoles with 1,3-diketones afforded 2-((benzotriazol-1-yl)carbonyl)pyrroles II [R2 = Me, Ph, 4-MeC6H4, 4-MeOC6H4; R3 = 2-thienyl, Ph, 4-MeC6H4, etc.] in moderate to good yields. Base-promoted annulations of 2-((benzotriazol-1-yl)carbonyl)pyrroles with aldehydes, ketones, isocyanates and isothiocyanates afforded various substituted pyrrolo[1,2-c]oxazole III [R4 = Ph, 4-MeOC6H4, 4-BrC6H4; R5 = Me, Ph; R6 = H, Me; R7 = H, Me; R6R7 = i-Pr, cyclohexyl, 4-MeC6H4, etc.] and 1H-pyrrolo[1,2-c]imidazole derivatives IV [R8 = Me, Ph, 4-MeC6H4; R9 = Me, Ph, Bn, etc.; X = O, S] in moderate to high yields. The 6-acyl group of these adducts could be removed by triflic acid, gave further new pyrrolo-fused O- and N-heterocycles, such as 6-unsubstituted pyrrolo[1,2-c]oxazol-1(3H)-one and 1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione, while the 6-acetyl substituent of 1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione, when treated with POCl3/pyridine, was transformed into the 6-ethynyl substituent. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Synthetic Route of C9H10O3S).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C9H10O3S
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics