Naphthyridines. I. Synthesis of (2-amino-3-pyridyl)diphenylcarbinols and their cyclization to 4-phenyl-2,3-benzo-1,8-naphthyridines was written by Konshin, M. E.;Chesnokov, V. P.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1973.Synthetic Route of C7H8N2O2 This article mentions the following:
Diphenylcarbinols (I; R = H, Cl, Br) were prepared in 63-70% yield by a Grignard reaction of PhMgBr with the appropriate Me 2-aminonicotinate. Heating I 2 hr in PhNO2 at 210-15° gave â?0% yield of benzonaphthyridines (II; R = H, Cl). In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Synthetic Route of C7H8N2O2).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C7H8N2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics