Synthesis of 22-bromodocosanol was written by Signer, R.;Sprecher, P.. And the article was included in Helvetica Chimica Acta in 1947.Recommanded Product: 12-Methoxy-12-oxododecanoic acid This article mentions the following:
For the study of the question whether on bromination of a mol. layer of Me(CH2)20CH2OH the Br enters the Me group or attacks the CH2 groups, BrCH2(CH2)20CH2OH (I) is synthesized for comparison. MeO2C(CH2)10CO2Me (44.4 g.) in 235 cc. MeOH is saponified with the calculated amount of N Ba(OH)2 in MeOH 2 days at room temperature with shaking, giving 49.6 g. Ba salt of the mono ester. This is converted with 17.5 g. Na2SO4 in 700 cc. H2O into the Na salt which is decomposed by adjusting the solution to pH 4, giving 85% MeO2C(CH2)10CO2H (II), m. 52°. When 14.4 g. II in 52 cc. MeOH containing 1 g. KOH is electrolyzed 12 hrs. at 600° (30-5 v., about 0.3 amp.), using Pt electrodes, 43% MeO2C(CH2)20CO2Me (III), m. 69-70°, is obtained. Reduction of III by pouring 2 g. in 42 cc. absolute BuOH at 90° over 2.8 g. Na and heating the mixture with stirring at 150°, and saponification of the unchanged ester by boiling it 1 hr. with H2O give 80% 1,22-docosanediol (IV), m. 102-2.5°. By determining the m.p. curve, it is found that on passing HBr into IV at 130° all the IV disappears after 12 min. and after 30 min. IV is almost completely converted into the 1,22-dibromide (V). For the preparation of I a rapid stream of HBr is passed into 2 g. IV at 110° for 1 min. After the excess HBr is expelled with dry air, the product is dissolved in 100 cc. PhMe and cooled to 0°, causing the quant. crystallization of the unchanged IV (1.4 g.). The filtrate is evaporated to dryness, the residue chromatographed from its C6H6 solution over Al2O3, giving pure I, m. 72°. The data of the x-ray diagrams of I and V are given in a table. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Recommanded Product: 12-Methoxy-12-oxododecanoic acid).
12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 12-Methoxy-12-oxododecanoic acid
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics