Atkinson, Benjamin N. published the artcileRegioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives, SDS of cas: 115314-17-5, the publication is Organic & Biomolecular Chemistry (2017), 15(46), 9794-9799, database is CAplus and MEDLINE.
A new efficient chiral synthesis of enantiopure arimoclomol is reported from (R)-(-)-glycidyl nosylate with complete retention of chiral integrity. Off-target pharmacol. of arimoclomol was evaluated against a representative set of drug targets and showed modest binding to a few kinases. Pharmacokinetic data was generated in vivo in mouse and showed a low brain : plasma ratio. These studies will be helpful towards a better understanding of the PK-PD relationship of arimoclomol in disease models.
Organic & Biomolecular Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, SDS of cas: 115314-17-5.
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