Zhang, Haiyan published the artcileCobalt-catalyzed diastereo- and enantioselective allyl addition to aldehydes and α-ketoesters through allylic C-H functionalization, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is homoallylic alc preparation diastereo enantioselective; aldehyde ketoester allylbenzene cobalt catalyst allyl addition.
Development of catalytic generation of allyl-metal complexes through allylic C-H cleavage of alkenes without prefunctionalization followed by site- and stereoselective carbon-carbon bond formation is of great importance in organic synthesis, providing a straightforward and step-economical approach to introduce a versatile allyl group into organic mols. Although significant advances have been achieved in enantioselective transformations of electrophilic allyl-metal complexes and allyl radicals, enantioselective reactions of nucleophilic allyl-metal intermediates furnished through allylic C-H cleavage remain undeveloped. Herein, authors identify a multi-tasking chiral catalyst derived from a com. available phosphine ligand and cobalt salt that precisely controls the chemoselective formation of the allyl-cobalt complex and the site- and stereoselective addition to carbonyls, delivering a broad scope of homoallylic alcs. with high yield and stereoselectivity. This work may establish a platform for the development of enantioselective transformations of nucleophilic organometallic complexes generated from catalytic C-H functionalization.
Cell Reports Physical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics