Tabarrini, Oriana published the artcileStructure Modifications of 6-Aminoquinolones with Potent Anti-HIV Activity, COA of Formula: C7H13NO2, the publication is Journal of Medicinal Chemistry (2004), 47(22), 5567-5578, database is CAplus and MEDLINE.
It was recently discovered that 6-aminoquinolone derivatives could be valid leads for the development of new anti-HIV agents because of their new and diversified mode of action. The studies carried out on the lead compound WM5 showed that this derivative is able to inhibit the Tat-mediated long terminal repeat driven transcription, an essential step in the HIV-1 replication cycle. Thus, starting from lead WM5, the design and synthesis of an enlarged series of 6-aminoquinolones, e.g. I (R1 = Me, 2-benzothiazolyl, biphenyl, 4-FC6H4, etc.; R2 = 2-MeOC6H4, 2-thiazolyl, 2-pyridyl, 5-methyl-1,3,4-thiadiazol-2-yl, etc.), was performed and their structure-activity relationship was studied. I (R1 = Me; R2 = 3-F3CC6H4, 2-thiazolyl, 2-pyrazinyl, 2-benzoxazolyl) proved to be highly effective in inhibiting HIV replication at 50% inhibitory concentration in the range of 0.0087-0.7 μg/mL in MT-4, PBMCs and CEM cell lines coupled with pos. selectivity indexes that reach values higher than 1000 on CEM cell lines for I (R1 = Me; R2 = 2-thiazolyl, 2-pyrazinyl). Time-of-addition experiments clearly confirm that the new, potent 6-aminoquinolones interact at a postintegration step in the replication cycle of HIV.
Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H15NO, COA of Formula: C7H13NO2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics