Duncan, Kenneth W. published the artcileStructure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666, Computed Properties of 115314-17-5, the publication is ACS Medicinal Chemistry Letters (2016), 7(2), 162-166, database is CAplus and MEDLINE.
The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific community with in vivo-active tool compound I (EPZ015666, GSK3235025) to probe the underlying pharmacol. of this key enzyme. Herein, the authors report the design and optimization strategies employed on an initial hit compound with poor in vitro clearance to yield in vivo tool compound I and an addnl. potent in vitro tool mol. II (GSK3203591).
ACS Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Computed Properties of 115314-17-5.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics