Research on new synthetic routes about 14062-25-0

The chemical industry reduces the impact on the environment during synthesis 14062-25-0. I believe this compound will play a more active role in future production and life.

The chemical industry reduces the impact on the environment during synthesis 14062-25-0, name is Ethyl 2-(4-bromophenyl)acetate, I believe this compound will play a more active role in future production and life. 14062-25-0

Step a: Diethyl 2-(4-bromophenyl)malonate To a solution of ethyl 2-(4-bromophenyl)acetate (5.0 g, 21 mmol) in dry THF (40 mL) at -78 C. was added a 2.0M solution of lithium diisopropylamide in THF (11 mL, 22 mmol). After stirring for 30 minutes at -78 C., ethyl cyanoformate (2.0 mL, 21 mmol) was added and the mixture was allowed to warm to room temperature. After stirring for 48 h at room temperature, the mixture was quenched with water (10 mL). The reaction was partitioned between 1 N HCl (50 mL) and dichloromethane (50 mL), and the organic layer was separated. The organic layer was washed with 1 N HCl (50 mL), dried over Na2SO4 and evaporated. The crude material was purified by silica gel chromatography, eluding with 0-20% ethyl acetate in hexanes to give diethyl 2-(4-bromophenyl)malonate (2.6 g, 41%) 1H NMR (400 MHz, DMSO-d6) delta 7.60-7.58 (m, 2H), 7.36-7.34 (m, 2H), 5.03 (s, 1H), 4.21-4.09 (m, 4H), 1.20-1.16 (m, 6H).

The chemical industry reduces the impact on the environment during synthesis 14062-25-0. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hadida Ruah, Sara S.; Miller, Mark T.; Bear, Brian; McCartney, Jason; Grootenhuis, Peter D. J.; US2008/9524; (2008); A1;,
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