Hu, Tianjiao published the artcileRu-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones, Application In Synthesis of 30414-53-0, the publication is Angewandte Chemie, International Edition (2021), 60(43), 23193-23196, database is CAplus and MEDLINE.
The Ru(II)-NHC-catalyzed asym. hydrogenation of 2-quinolones under mild reaction conditions was developed. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones I [R = H, Me; R1 = Me, Bn; R2 = H, Me, Et, i-Pr, Ph; R3 = H; R4 = H, Me, Ph, etc.; R5 = H, OMe, F, etc.; R6 = H, Me; R1R3 = (CH2)3] were obtained in high yields with moderate to excellent enantioselectivities. The reaction provided an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.
Angewandte Chemie, International Edition published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Application In Synthesis of 30414-53-0.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics