Hess, Stefan published the artcileApproach to the Core Structure of Streptosetin A, Computed Properties of 539-88-8, the main research area is streptosetin A core synthesis.
Streptosetin A (I) belongs to the 3-decalinoyltetramic acids. In contrast to most of other known natural products of this type, the decalin part features a β-hydroxyketone subunit, making an intramol. cycloaddition approach less suitable. We examined an approach where the decalin part would be fashioned by an intramol. aldol addition By using a Diels-Alder reaction between the Rawal diene and a substituted methacrylate, a cyclohexanone was obtained. An organocuprate addition introduced the Et substituent before, the side chain was converted to an enal. However, contrary to our expectations, the aldol reaction led to the condensation product. Other routes to reach the key cyclohexanone were also investigated.
ChemistrySelect published new progress about streptosetin A core synthesis. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics