Marti, Guillaume published the artcileComparison of the phytochemical composition of Serenoa repens extracts by a multiplexed metabolomic approach, SDS of cas: 111-11-5, the main research area is Serenoa metabolomics ethanol extract phytochem composition; Saw palmetto; Serenoa repens extract; metabolomics; natural products; phytochemical equivalence.
Phytochem. extracts are highly complex chem. mixtures In the context of an increasing demand for phytopharmaceuticals, assessment of the phytochem. equivalence of extraction procedures is of utmost importance. Compared to routine anal. methods, comprehensive metabolite profiling has pushed forward the concept of phytochem. equivalence. In this study, an untargeted metabolomic approach was used to cross-compare four marketed extracts from Serenoa repens obtained with three different extraction processes: ethanolic, hexanic and sCO2 (supercritical carbon dioxide). Our approach involved a biphasic extraction of native compounds followed by liquid chromatog. coupled to a high-resolution mass spectrometry based metabolomic workflow. Our results showed significant differences in the contents of major and minor compounds according to the extraction solvent used. The analyses showed that ethanolic extracts were supplemented in phosphoglycerides and polyphenols, hexanic extracts had higher amounts of free fatty acids and minor compounds, and sCO2 samples contained more glycerides. The discriminant model in this study could predict the extraction solvent used in com. samples and highlighted the specific biomarkers of each process. This metabolomic survey allowed the authors to assess the phytochem. content of extracts and finished products of S. repens and unequivocally established that sCO2, hexanic and ethanolic extracts are not chem. equivalent and are therefore unlikely to be pharmacol. equivalent
Molecules published new progress about Biomarkers. 111-11-5 belongs to class esters-buliding-blocks, name is Methyl octanoate, and the molecular formula is C9H18O2, SDS of cas: 111-11-5.
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